Dr. Fadi Issa - East Carolina University

Publications

24. Heagy FK, Clements KN, Adams CL, Blain E, Issa FA (2024). Socially induced plasticity of the posterior
tuberculum and motor behavior in zebrafish (Danio rerio). Journal of Experimental Biology.

23. Clements KN, Ahn S, Park C, Heagy FK, Miller TH, Kassai M, Issa FA (2023). Socially mediated shift in
neural circuit activation regulated by synergistic neuromodulatory signaling. eNeuro.

22. Scott E, Brewer MS, Peralta A, Issa FA (2023). The effects of social experience on host gut microbiome
composition in male zebrafish (Danio rerio). The Biological Bulletin.

21. Issa FA, Hall MK, Hatchett CJ, Weidner DA, Fiorenza A, Schwalbe RA (2021). Compromised
N-glycosylation processing of Kv3.1b correlates with perturbed motor neuron structure and locomotor
activity. Biology (Basel).

20. Carver JJ, Carrell SC, Chilton MW, Brown JN, Yong L, Zhu Y, Issa FA (2021). Nuclear androgen and
progestin receptors inversely affect aggression and social dominance in male zebrafish. Hormones and
Behavior.

19. Orr SA, Ahn S, Park C, Miller TH, Kassai M, Issa FA (2021). Social experience regulates
endocannabinoids modulation of zebrafish motor behaviors. Frontiers in Behavioral Neuroscience.

18. Hsieh JY, Ulrich BN, Issa FA, Lin MA, Brown B, Papazian DM. (2020). Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo. eLife 2020;9:e57358.

17. Bacque-Cazenave J, Fossat P, Issa FA, Edwards DH, Delbecque JP, Cattaert D. (2019). Duality of 5-HT effects on crayfish motoneurons. Frontiers in Physiology doi: 10.3389/fphys.2019.01280

16. Clements KN, Miller, TH, Keever, J, Hall AM, Issa FA (2018). Social status related differences in motor activity between wild type and mutant zebrafish. The Biological Bulletin 235 (2): 71-82.

15. Park C, Clements KN, Issa FA, Ahn S (2018). Neural mechanisms underlying social status-dependent habituation of the Mauthner escape circuit in zebrafish (Danio rerio): Empirical and computational analysis. Frontiers in Neural Circuits. doi:10.3389/fncir.2018.00007s

14. Miller TH, Clements K, Ahn S, Park C, Ji EH, Issa FA (2017). Social status-dependent shift in neural

circuit activation affects decision-making. The Journal of Neuroscience 7(8):2137-2148.

News Highlights: Proceedings of the National Academy of Sciences.

13. Park C, Miller TH, Clements KN, Ahn S, Ji EH, Issa FA (2016). Social stress induced neural network
    reconfiguration affects decision making and learning in zebrafish. BMC Neuroscience 17(1): 82-83.

12. Hsieh JY, Ulrich B, Issa FA, Wan J, Papazian DM (2014). Rapid development of Purkinje cell excitability,
    functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish. Frontiers in Neural
     Circuits 8:147.

11. Bacque-Cazenave J, *Issa FA, Edwards DH, Cattaert D (2013). Spatial segregation of excitatory and
      inhibitory effects produced by 5-HT cell on depressor motoneurons of the crayfish walking leg postural
      circuit. Journal of Neurophysiology 109(11): 2793-2802 (*equal first authorship).

10. Issa FA, Mock AF, Sagasti A, Papazian DM (2012). Spinocerebellar ataxia type 13 mutation associated
      with disease onset infancy disrupts axonal pathfinding during neuronal development.
      Disease Models & Mechanisms 5(6):921-929.

9. Issa FA, Drummond J, Cattaert D, Edwards DH (2012). Neural circuit reconfiguration by social status.
    The Journal of Neuroscience 32(16):5638-5645.

8. Issa FA, Mazzochi C, Mock, AF, Papazian DM (2011). Spinocerebellar ataxia type 13 mutant potassium
   channel alters neuronal excitability and causes locomotor deficits in zebrafish. The Journal of
   Neuroscience 31(18):6831-6841.

7. Issa FA, O’Brien G, Kettunen P, Sagasti A, Glanzman DL, Papazian DM (2011). Neural circuit activity
    in freely behaving zebrafish (Danio rerio). Journal of Experimental Biology 214(Pt6):1028-1038.

6. Cattaert D, Delbecque JP, Edwards DH, Issa FA (2010). Social interactions determine postural network
    sensitivity to 5HT. The Journal of Neuroscience 30(16): 5603-5616.

5. Issa FA, Edwards DH (2006). Ritualized submission and the reduction of aggression in an invertebrate.
Current Biology 16(22):2217-2221. News Coverage:

Scientific American: Most Important Science Stories of 2006

4. Edwards DH, Issa FA, Herberholz J (2003). The neural basis of dominance hierarchy formation in
    crayfish. Microscopy Research & Techniques 60(3):369-376.

3. Drummond J, Issa FA, Song, C-K, Herberholz J, Edwards DH (2001). Neural mechanisms of
      dominance hierarchies in crayfish, in: The Crustacean Nervous System, Editors K. Wiese and
      M.Schmidt. Springer Verlag, Berlin.

2. *Herberholz J, *Issa FA, Edwards DH (2001). Patterns of neural circuit activation and behavior during
     dominance hierarchy formation in freely behaving crayfish. The Journal of Neuroscience 21(8):2759-2767.
     (*equal first authorship).

1. Issa FA, Adamson DJ, Edwards DH (1999). Dominance hierarchy formation in juvenile crayfish,
    Procambarus clarkii. Journal of Experimental Biology 202(Pt 24):3497-3506.

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Last updated: 1/15/24