Current Funding

Ongoing Research Support:

NSF MCB-0842475    Keiper (PI)              4/1/09 to 3/31/12
NSF

Translational control of growth and apoptosis in C. elegans development by initiation factors.

Building on previous findings showing specific roles for eIF4E and eIF4G isoforms in sperm and oocyte development, this study addresses how these factors isoforms preferentially select controlled mRNAs for protein synthesis in gametes to promote their maturation, or to undergo apoptosis.
Role:  Principle Investigator

Instrumentation Grant Support:

2004-IDG 1002        Keiper and McCubrey (co-PI's)      2/1/05 to 1/31/06
North Carolina Biotechnology Center, Institutional Development Grant

Phosphor-Imaging and Fluorescence-Imaging Core Facility (Brody School of Medicine at ECU)

Funds were awarded for the purchase of a multipurpose gel and array scanning facility to visualize and quantify radioactive, fluorescent and chemiluminescent signals.
Role:  Principle Investigator

Completed Research Support:

Research Development Award    Keiper (PI)              7/1/08 to 6/30/09
Division of Research and Graduate Studies, ECU

Translational control of growth and apoptosis in the C. elegans ovary.

The regulation of growth promoting vs. apoptosis-promoting protein synthesis by initiation factor isoform is the focus of this bridge grant.
Role:  Principle Investigator

NSF MCB-0321017    Keiper (PI)              1/1/04 to 12/31/08
NSF

Function of tissue-specific eIF4E isoforms in Caenorhabditis elegans

This study addresses how initiation factor isoforms govern translational control of gene expression in embryogenesis and gametogenesis.
Role:  Principle Investigator

Leo W. Jenkins Cancer Research Grant     Farwell and Keiper (coPI's)      1/06 to 12/06
Leo W. Jenkins Cancer Center, Pilot/Collaborative Research Grants
Targeted depletion of isoforms in breast cancer cell lines reduces proliferation and increases apoptosis.
This study looks at blocking expression of specific translation initiation factor eIF4G isoforms to see if proliferation is inhibited and apoptosis promoted.
Role:  Co-Principle Investigator


ECU ACS-IRG 5-89812        Keiper (PI)               7/1/03 to 6/30/04
American Cancer Society
Reducing Cell Proliferation by Translation Factor eIF4G Depletion: C. elegans as a model for transformed cells
This study probes the role of translation factor eIF4G in the rapid growth characteristic of embryonic and cancer cells.

Role:  Principle Investigator