Ongoing Research Support:
4/1/09 to 3/31/12
Translational control of growth and apoptosis in C. elegans development by initiation factors.
on previous findings showing specific roles for eIF4E and eIF4G isoforms in
sperm and oocyte development, this study addresses how these factors isoforms
preferentially select controlled mRNAs for protein synthesis in gametes to
promote their maturation, or to undergo apoptosis.
Instrumentation Grant Support:
Phosphor-Imaging and Fluorescence-Imaging Core Facility (Brody School of Medicine at ECU)
were awarded for the purchase of a multipurpose gel and array scanning
facility to visualize and quantify radioactive, fluorescent and
Translational control of growth and apoptosis in the C. elegans ovary.
regulation of growth promoting vs. apoptosis-promoting protein synthesis by
initiation factor isoform is the focus of this bridge grant.
1/1/04 to 12/31/08
Function of tissue-specific eIF4E isoforms in Caenorhabditis elegans
study addresses how initiation factor isoforms govern translational control
of gene expression in embryogenesis and gametogenesis.
Role: Principle Investigator